Metallic particles as silver and gold subvisible ones are suspensions of submicron / micron sized particles typically dispersed in aqueous solution. The suspension color changes as the particle changes sizes, shape, or surface roughness due to the surface plasmon, which ultimately modifies the effective refractive index of the particles.
In the last few years, metallic particles have become of great interest for researchers in many fields thanks to their unique physical and optical properties, and are especially investigated for pharmacological and life science applications as a vehicle for drugs and genes. The particle surface is commonly coated with various payloads such as small drug molecules, proteins, DNA, etc.
Classizer™ ONE is capable to discriminate all little shape and structural modifications of metallic particles. This allows to classify e.g. silver and gold subvisible particles in terms of size and shape or surface roughness, in aqueous solution as well as in complex biological fluids (serum, humor, blood, etc.). Classizer™ ONE will provide a thorough characterization of metallic particles with just a few minutes of analysis, without additional expensive characterization.
The case of gold nanoparticle with same size but different shapes
(in figure) Gold 80nm spheres and 60nm/160nm stars present very specific distribution on the 2D histogram, thus allowing Classizer™ ONE to easily recognize and classify them.